A Mechanistic Insight into the Pathogenic Role of Interleukin 17A in Systemic Autoimmune Diseases

<div>Schematic representation of IL-17 family of cytokines and receptors. IL-17A is the front runner in the IL-17 family of cytokines, comprising six homologues IL-17A to IL-17F in total. The IL-17 receptor family consists of five canonical IL-17 receptors, named IL-17RA to RE; CD93 has recently been identified as receptor for IL-17D. SEFIR: similar expression of fibroblast growth factor and IL-17Rs; SEFEX: SEFIR extension; CBAD: C/EBP<i>β</i> activation domain.</div>

Mediators of Inflammation

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Figure 1

Figure 1: A Mechanistic Insight into the Pathogenic Role of Interleukin 17A in Systemic Autoimmune Diseases 