Sodium Butyrate Attenuates Diabetic Kidney Disease Partially via Histone Butyrylation Modification

Figure 1

NaB ameliorates glucose and lipid metabolism disorder in DKD mice. Mice were subjected to a high-fat diet (HFD) for 8 weeks, intraperitoneally (i.p.) injected with STZ, and then treated with sodium butyrate (NaB), for 12 weeks. Body weight (BW) (a) and random blood glucose (RBG) (b) were measured every 2 weeks; fasting blood glucose (FBG) (c), low-density lipoprotein-cholesterol (LDL-C) (d), total cholesterol (TC) (e), and total glyceride (TG) (f) values were measured at the 20th week of the experiment before sacrifice. Values are presented as the . .

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