Human Neutrophil Defensins Disrupt Liver Interendothelial Junctions and Aggravate Sepsis

<div>Effect of the administration of various doses of HNP-1 on liver endothelial cell death during sepsis progression. Wild-type mice were intraperitoneally administered a high dose of HNP-1 (10 mg/kg body weight), a low dose of HNP-1 (0.5 mg/kg body weight), or PBS 6 hours after CLP. (a) Quantification of pyroptotic endothelial cells in the liver at 48 hours after CLP using flow cytometry. 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(b) Quantification of apoptotic endothelial cells in the liver at 48 hours after CLP using flow cytometry. 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Mediators of Inflammation

fig5

Figure 5

Figure 5: Human Neutrophil Defensins Disrupt Liver Interendothelial Junctions and Aggravate Sepsis 