Genetic Variations in Nucleotide Excision Repair Pathway Genes and Risk of Allergic Rhinitis
Table 1
Association between polymorphisms in nucleotide excision repair pathway genes and allergic rhinitis susceptibility.
Gene
SNP
Allele
Case ()
Control ()
Adjusted OR a
a
Adjusted ORb
b
HWE
A
B
AA
AB
BB
AA
AB
BB
(95% CI)
(95% CI)
ERCC1
rs2298881
C
A
225
231
52
205
231
90
0.89 (0.64-1.24)
0.493
0.30 (0.18-0.50)
<0.0001
0.075
ERCC1
rs3212986
C
A
199
242
67
243
222
61
1.38 (0.99-1.92)
0.060
1.14 (0.69-1.87)
0.617
0.346
ERCC1
rs11615
G
A
261
204
43
297
185
44
1.44 (1.04-2.01)
0.030
0.99 (0.54-1.81)
0.975
0.052
XPA
rs1800975
T
C
142
277
89
126
276
124
0.74 (0.51-1.07)
0.106
0.78 (0.52-1.17)
0.277
0.257
XPA
rs3176752
G
T
357
138
13
395
123
8
1.01 (0.70-1.46)
0.942
1.48 (0.49-4.53)
0.489
0.653
XPC
rs2228001
A
C
227
220
61
208
251
67
0.68 (0.49-0.95)
0.024
0.88 (0.53-1.47)
0.632
0.517
XPC
rs2228000
C
T
184
247
77
206
249
71
1.12 (0.80-1.56)
0.527
1.44 (0.90-2.31)
0.131
0.756
XPC
rs2607775
C
G
463
45
0
473
53
0
0.90 (0.50-1.60)
0.718
/
/
0.224
XPC
rs1870134
G
C
317
161
30
335
165
26
1.18 (0.84-1.65)
0.338
1.27 (0.62-2.59)
0.514
0.335
XPC
rs2229090
G
C
168
249
91
196
252
78
1.21 (0.86-1.70)
0.276
1.28 (0.82-1.98)
0.274
0.837
XPD
rs3810366
G
C
148
265
95
146
251
129
1.05 (0.73-1.51)
0.782
0.87 (0.58-1.30)
0.494
0.306
XPD
rs238406
G
T
114
266
128
152
248
126
1.22 (0.84-1.79)
0.294
0.94 (0.64-1.38)
0.753
0.209
XPD
rs13181
T
G
436
69
3
456
66
4
1.21 (0.75-1.95)
0.447
2.90 (0.51-16.32)
0.228
0.351
XPF
rs2276466
C
G
289
195
24
299
195
32
0.94 (0.67-1.31)
0.709
0.74 (0.35-1.58)
0.441
0.978
XPG
rs2094258
C
T
214
231
63
201
249
76
0.78 (0.56-1.08)
0.132
0.89 (0.55-1.44)
0.640
0.937
XPG
rs751402
C
T
205
235
68
209
235
82
0.85 (0.61-1.19)
0.347
1.04 (0.66-1.64)
0.851
0.241
XPG
rs2296147
T
C
321
165
22
341
166
19
1.27 (0.90-1.79)
0.172
0.79 (0.34-1.86)
0.589
0.828
XPG
rs1047768
T
C
270
200
38
309
189
28
1.33 (0.96-1.85)
0.092
1.29 (0.68-2.48)
0.438
0.897
XPG
rs873601
G
A
124
244
140
132
269
125
0.97 (0.66-1.42)
0.865
1.45 (1.00-2.12)
0.053
0.598
OR: odds ratio; CI: confidence interval; HWE: Hardy–Weinberg equilibrium. The results were in bold if the 95% CI excluded 1 or .aAdjusted for age and sex for dominant model. bAdjusted for age and sex for recessive model.
