Genetic Variations in Nucleotide Excision Repair Pathway Genes and Risk of Allergic Rhinitis

Table 2

Stratification analysis of ERCC1 and XPC genotypes with allergic rhinitis risk.

Variables

ERCC1; rs2298881; (case/control)

AOR (95% CI)

^a

ERCC1; rs11615; (case/control)

AOR (95% CI)

^a

XPC; rs2228001; (case/control)

AOR (95% CI)

^a

CC/CA

AA

GG

GA/AA

AA

AC/CC

Age, month

≤60

153/356

11/66

0.40 (0.20-0.77)

0.007

78/237

86/185

1.40 (0.97-2.01)

0.072

73/175

91/247

0.89 (0.62-1.28)

0.522

>60

303/80

41/24

0.46 (0.26-0.80)

0.007

183/60

161/44

1.20 (0.77-1.87)

0.419

154/33

190/71

0.58 (0.37-0.93)

0.022

Sex

Females

235/205

22/36

0.25 (0.12-0.55)

0.0004

132/129

125/112

1.37 (0.84-2.22)

0.209

120/98

137/143

0.66 (0.40-1.08)

0.094

Males

221/231

30/54

0.35 (0.18-0.68)

0.002

129/168

122/117

1.52 (0.97-2.39)

0.068

107/110

144/175

0.70 (0.44-1.10)

0.120

Clinical stages

I

130/436

17/90

0.44 (0.23-0.85)

0.015

80/297

67/229

1.24 (0.79-1.95)

0.341

79/208

68/318

0.44 (0.28-0.69)

0.0004

II

208/436

19/90

0.24 (0.12-0.46)

<0.0001

108/297

119/229

1.47 (0.99-2.18)

0.058

84/208

143/318

0.89 (0.59-1.34)

0.587

III

118/436

16/90

0.39 (0.20-0.79)

0.009

73/297

61/229

1.24 (0.77-2.00)

0.369

64/208

70/318

0.51 (0.31-0.82)

0.006

CI: confidence interval; AOR: adjusted odds ratio. The results were in bold if the 95% CI excluded 1 or . ^aObtained in logistic regression models with adjustment for age and sex omitting the corresponding stratification factor.