Gasdermin D Deficiency Does Not Protect Mice from High-Fat Diet-Induced Glucose Intolerance and Adipose Tissue Inflammation

Figure 1

Body weight and food intake in wild-type (WT) and gasdermin D knockout (GSDMD KO) mice fed a high-fat diet (HFD). (a and b) Measurements of changes in body weight during a HFD or normal chow diet (NCD) in WT and GSDMD KO mice. (c and d) Measurements of food intake in WT and GSDMD KO mice fed a NCD or HFD. (e–g) Tissue weight and ratio of tissue weight per body weight in subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and liver. vs. same genotype mice fed a NCD and ^# vs. WT HFD group.

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