Gasdermin D Deficiency Does Not Protect Mice from High-Fat Diet-Induced Glucose Intolerance and Adipose Tissue Inflammation

Figure 2

Glucose and insulin tolerance in wild-type (WT) and gasdermin D knockout (GSDMD KO) mice fed a high-fat diet (HFD). (a) Oral glucose tolerance test and (b) intraperitoneal insulin tolerance test performed at 15 weeks on a HFD in WT and GSDMD KO mice. Blood glucose levels were measured and the area under the curve (AUC) was determined. (c) Oral glucose tolerance test and (d) intraperitoneal insulin tolerance test performed at 30 weeks on a HFD in WT and GSDMD KO mice. Plasma IL-1β (e) and IL-18 (f) measured by ELISA. vs. same genotype mice fed a NCD, ^† vs. WT NCD group, and ^# vs. WT HFD group.

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