Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis

Figure 1

CI/R caused behavior deficits, cerebral ischemic lesion, and neuronal death in the rat MCAO model. Rats were treated with MCAO. (a) CI/R injured the gait of rats. Representative footprints of the rats are shown in each group. (b) The quantification of gait stride length (mm) (). (c) Neurological severity scores of each group evaluated after reperfusion (). (d) Cerebral ischemic lesion volume was detected by TTC, representative TTC-stained brain sections showing areas of healthy tissue (red) and ischemic injury (white) in different groups (). (e) Quantitative analysis of ischemic lesion volume (). (f) Haematoxylin-eosin (H&E) staining of the rat brain slices of each group in the hippocampal CA1 region (). (g) Nissl-stained sections indicated that C/IR increased neuronal death in the hippocampal CA1 region of rats (). Each bar represents the . , , , and were statistically significant.

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