Arsenic Induces Continuous Inflammation and Regulates Th1/Th2/Th17/Treg Balance in Liver and Kidney In Vivo

Table 1

Average daily arsenic intake in drinking water, the concentrations of total arsenic (T-As, ng As/g tissue) of the liver and kidney, the body weight and liver and kidney weights in control and different experimental mice.

Experimental groups	Duration (months)	Dose (mg/L)	Calculated average daily arsenic intake (mg NaAsO2/kg body weight/day)	T-As in liver (ng/g)	T-As in kidney (ng/g)	Body weight (g)	Liver weight (g)	Kidney weight (g)
Group 1	1	0	0	<LD	<LD
Group 2	1	25
Group 3	1	50					1
Group 4	3	0	0	<LD	<LD			0.29 ± 0.03
Group 5	3	25
Group 6	3	50	6.47 ± 0.33

Mice were treated with 25 and 50 mg/L NaAsO₂ by drinking water for 1 and 3 months, and total arsenic (T-As) levels of the liver and kidney were determined by the high-performance liquid chromatography-hydride generation-atomic fluorescence spectrometry (HPLC-HG-AFS) method, as described in Materials and Methods. Results were expressed as (). The limit of detection (LD) for T-As was 1 μg/L. Denoted compared with control mice.