Vitronectin, a Novel Urinary Proteomic Biomarker, Promotes Cell Pyroptosis in Juvenile Systemic Lupus Erythematosus

Figure 1

Profile of urinary proteins. (a) Heatmap shows the differentially expressed genes (DEGs) reflected by differentially expressed matching proteins in the indicated groups (group 1/G1: healthy controls, group 2/G2: inactive JSLE patients, and group 3/G3: active JSLE patients). Red and green colors indicate higher and lower expression, respectively. (b–e) Volcano dot plot presents the mass spectrometry data of proteome as -log10 ( value) plotted against the log2 (fold change/FC). The -log10 ( value) and log2 (FC) analysis thresholds are indicated by dotted lines (≥1.3-fold upregulation or ≤0.77-fold downregulation, ). Green dots represent the downregulated proteins, while red dots represent the upregulated proteins and gray dots represent no significant difference in proteins. The symbol of differentially expressed proteins labeled with relevant color is listed beside each graph.

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