Glibenclamide Alleviates LPS-Induced Acute Lung Injury through NLRP3 Inflammasome Signaling Pathway

Figure 3

The inhibition role of glibenclamide in the NLRP3/Caspase-1/IL-1β signaling pathway induced by LPS. (a) Relative NLRP3 mRNA expression in lungs was measured by real-time PCR (). (b, c) Representative images of Western blot of NLRP3 and Caspase-1/p20 in the lungs and quantitative analysis (). (d, e) Representative images of immunohistochemical staining of NLRP3 in the lungs and quantitative analysis (). Scale bars, 100 μm. Data are representative of three independent experiments (mean and SD). ns: not significant. , , , and (unpaired Student’s -test).

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