circ-Katnal1 Enhances Inflammatory Pyroptosis in Sepsis-Induced Liver Injury through the miR-31-5p/GSDMD Axis

Figure 1

CLP-induced sepsis promoted liver injury by increasing inflammatory pyroptosis. Mice were sacrificed 12 h after CLP, and liver tissues and serum were collected for further analysis. (a, b) ALT and AST expression levels were measured using ELISA. Data were presented as . ^∗∗∗, versus the sham group. (c, d) HE and TUNEL staining showed the liver injury (magnification, ×200). (e)–(g) ELISA detection showed the expression of inflammatory factors TNF-α, IL-1β, and IL-6. Data were presented as . ^∗∗∗, versus the sham group. (h, i) Western blot detection showed GSDMD, caspase-1, and NLRP3 expression. Data were presented as . ^∗∗∗, versus the sham group.

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