Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications

Figure 2

The role of Fyn in reperfusion injury. Increased Fyn activity leads to hyperphosphorylation of the NMDAR2B subunit and IP3R, which leads to increased calcium influx and subsequent excitotoxicity. Fyn phosphorylates PKCδ, leading to activation of NF-κB and causing entry of the P65 component into the nucleus. P65 entry into the nucleus leads to transcription of proinflammatory cytokine genes, such as IL-1β.