Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications

Table 1

The inhibitors of Fyn and Targets.

Fyn inhibitor	Target	Effects
Saracatinib	c-yes, Fyn, Lyn, Blk, Fgr, and Lck	Alleviate microglia, astrogliosis, neurodegeneration, and nitro-oxidative stress
PP1	Lck/Fyn	Reduced cerebral infarct size and neurologic dysfunction
PP2	Lck/Fyn	Inhibition of BBB leakage and reduction of infarct volume
ON123300	CDK4, Ark5/NUAK1, PDGFRβ, FGFR1, RET (c-RET), and Fyn	Improve OGD/R induced apoptotic cell death and the expression of p-Rb, B-myb, and Bim