Atractylenolide III Improves Mitochondrial Function and Protects Against Ulcerative Colitis by Activating AMPK/SIRT1/PGC-1α

Figure 2

AT III ameliorates DSS-induced inflammation and oxidative stress. (a, b) H&E staining of colon tissues and quantification of histological scores. Scale bar: 200 μm. (c) Immunohistochemical detection of MPO in colons. Scale bar: 50 μm. (d–g) qPCR results of TNF-α, IL-6, COX-2, and iNOS mRNA in colons. (h–j) ELISA measurements of MDA and GSH content, as well as SOD activity. ^$, compared to control; ^&, compared to DSS.

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