Expression of Thymic Stromal Lymphopoietin in Immune-Related Dermatoses

Figure 2

TSLP was significantly expressed in the epidermis in LP, BP, eczema, PsV, sarcoidosis, and MF and nonsignificantly expressed in DLE, in a semiquantitative analysis. (a) TSLP was significantly expressed in the stratum basale of the epidermis with PsV and sarcoidosis specimens. (b) TSLP was significantly expressed in the stratum spinosum of LP, eczema, BP, PsV, and MF. (c) TSLP expression in the stratum basale was significantly higher than that in the stratum spinosum in sarcoidosis specimens and was significantly lower in the stratum spinosum in LP specimens, but not significant in other dermatoses. The mean gradient of stratum basale and stratum spinosum expression of TSLP in sarcoidosis was different from in LP, eczema, BP, and MF, respectively. The score of each section was graded semiqualitatively on a scale of 0–3 (0: negative, 1: mild, 2: moderate, and 3: strong) blindly by two dermatologists in five randomly visual fields at high power field (HPF, ×400 magnification) of scanned sections. The gradient of the stratum basale and the stratum spinosum was mathematically calculated by subtracting the stratum basale score from stratum spinosum. values were determined by the one-group Student -test. Significant differences are noted between the groups: n.s.: not significantly different; ; .

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