Cell-Free DNA, Neutrophil extracellular traps (NETs), and Endothelial Injury in Coronavirus Disease 2019– (COVID-19–) Associated Acute Kidney Injury

Table 1

Baseline demographics of the Cincinnati Emergency Department COVID-19 cohort.

Variable	All patients ()	KDIGO AKI stage		Value
		Age (years): median (IQR)	50.5 (41-66)		47 (37.5-64)	66 (56.5-70.2)	0.005
Sex (male): (%)	31	24 (77.4%)	7 (22.6%)	1.000
Race:(%)
Black	20	11 (55.0%)	9 (45.0%)	0.036
Hispanic	19	18 (94.7%)	1 (5.3%)
White	9	7 (77.8%)	2 (22.2%)
Other	3	3 (100%)	0 (0%)
Comorbidities:(%)
Coronary artery disease	8	3 (37.5%)	5 (62.5%)	0.012
Heart failure	9	3 (33.3%)	6 (66.7%)	0.003
Hypertension	25	14 (56.0%)	11 (44.0%)	0.002
Hyperlipidemia	15	11 (73.3%)	4 (26.7%)	0.730
Obesity	18	16 (88.8%)	2 (11.1%)	0.086
Diabetes	20	14 (70.0%)	6 (30.0%)	0.512
Chronic obstructive pulmonary disease	8	4 (50%)	4 (50%)	0.076
Asthma	8	6 (75%)	2 (25%)	1.000
Chronic kidney disease	6	1 (16.7%)	5 (83.3%)	0.002
Chronic liver disease	7	3 (42.9%)	4 (57.1%)	0.044
Cerebrovascular disease	1	0 (0%)	1 (100%)	0.375
Acquired immunodeficiency (HIV, transplant)	3	2 (66.7%)	1 (33.3%)	1.000
Autoimmune disease	2	2 (100%)	0 (0%)	1.000

AKI, acute kidney injury; HIV, human immunodeficiency virus; IQR, interquartile range; KDIGO, kidney disease: improving global outcomes. Bold values indicate statistical significance.