Research Article

Interleukin-37b Suppressed ILC2s in Children with Allergic Rhinitis

Figure 3

The ILC2 cell proliferation and cytokine expression regulated by IL-37b in AR patients. (a) The proliferation of ILC2 was determined using tritiated thymidine incorporation under IL-37b stimulation. (b, c) The expression of IL-5 and IL-13 by ILC2 under IL-37b stimulation was assessed by ELISA. (d–f) The mRNA expression of IL-1R8, IL-18Rα, and ICOSL by ILC2 after stimulated by IL-37b. Three independent tests were performed for every experiment. ILC2: type 2 innate lymphoid cells; ICOSL: inducible T cell costimulator ligand. Compared with the PBS group, ; #Compared with the IL-37b (10 ng/mL) group, .
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