IFN-α-2b Reduces Postoperative Arthrofibrosis in Rats by Inhibiting Fibroblast Proliferation and Migration through STAT1/p21 Signaling Pathway

Figure 7

Crosstalk between STAT1/P21 and TGFβ/Smad signaling pathways. (a) Western blotting showed the expression levels of p-Stat1, Smad7, p-Smad3, and collagen I in different groups. (b) The analysis results showed that IFN-α-2b significantly reduced the relative expression levels of p-Smad3 and collagen I, while increasing the relative expression levels of p-STAT1 and Smad7. Within the fludarabine prestimulation group, the effect trend was partially reversed. Compared with the IFN-α-2b group, the change trend of p-Smad3 and collagen I was enhanced in the SIS3 prestimulation group, but only the former had statistical significance, while p-STAT1 and Smad7 had no significant change. The histogram shows the results of three repeated detections of the gray value of the Western blot band. Compared with the IFN-α-2b group, ().

(a)

(b)