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| Tested agents (CAS number) | Pharmacological class | Known pharmacological activities | Drug concentration range |
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| Isosorbide mononitrate (16051-77-7) | Nitrate-class drug which can release nitric oxide and active cGMP in the endothelium cell. | Dilate the blood vessels to reduce blood pressure. | 50-1000 μg/ml |
| Digoxin (20830-75-5) | Decrease the function of the Na+/K+ATPase pump so as to raise the calcium concentration in myocardiocytes. | Slightly increase myocardial contractility and decrease the heart rate and blood pressure. | 30-2000 ng/ml |
| Nitroglycerin (55-63-0) | Nitrate-class drugs. | Vasodilation widening of the blood vessels. | 3-100 ng/ml |
| Bisoprolol fumarate (104344-23-2) | Selective type β1 adrenergic receptor blocker in the heart muscle cells and heart conduction tissue. | Less contractility of the heart muscle and lowered heart rate. | 10-500 ng/ml |
| Metoprolol Tartrate (56392-17-7) | Selective β1 receptor blocker. | Decrease the heart rate and contraction. | 0.05-100 μg/ml |
| Amiodarone hydrochloride (19774-82-4) | Class III antiarrhythmic agent and prolongs phase 3 of the cardiac action potential. | Slows intracardiac conduction of the cardiac action potential. | 0.5-4 μg/ml |
| Lidocaine hydrochloride (137-58-6) | A common local anesthetic and antiarrhythmic drug. | Class 1B antiarrhythmic drug, decreases the ventricular rate. | 1-100 μg/ml |
| Propafenone hydrochloride (34183-22-7) | Slowing the influx of sodium ions into the cardiac muscle cells. | Decrease in excitability of the cardiac muscle cells. | 500-2000 ng/ml |
| Amlodipine (88150-42-9) | Dihydropyridine class, a long-acting calcium channel blocker. | Relax the smooth muscle in the arterial wall, decreasing total peripheral resistance and hence reducing blood pressure. | 5-1000 ng/ml |
| Carvedilol (72956-09-3) | Beta blockers (β1, β2) and alpha blocker (α1). | Slow the heart rhythm and reduce the force of the heart’s pumping. Lower blood pressure and reduce heart failure. | 10-200 ng/ml |
| Dopamine hydrochloride (62-31-7) | Catecholamine neurotransmitter. | Increased heart rate and blood pressure. | 5-100 μg/ml |
| Irbesartan (138402-11-6) | Angiotensin II receptor antagonists. | Modulate the renin–angiotensin-aldosterone system. | 0.04-4 μg/ml |
| Spironolactone (52-01-7) | Synthetic steroid. | Inhibits the effect of aldosterone and decreases the reabsorption of sodium and water. | 0.1-1000 μg/ml |
| Epinephrine hydrochloride (55-31-2) | A hormone and a neurotransmitter. | Increases heart rate and constricts blood vessels. | 0.01-2 μg/ml |
| Rosuvastatin Calcium (147098-20-2) | A member of the drug class of statins. | A competitive inhibitor of the enzyme HMG-CoA reductase, reduce the level of LDL cholesterol. | 10-2000 ng/ml |
| Clopidogrel (113665-84-2) | Thienopyridine class antiplatelet agent, irreversibly inhibiting a receptor called P2Y12, an adenosine diphosphate ADP chemoreceptor. | Inhibit blood clots. | 15-1000 μg/ml |
| Ticlopidine (55142-85-3) | An antiplatelet drug in the thienopyridine family. | Inhibits platelet aggregation and prolongs bleeding time. | 10-200 μg/ml |
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