Association of Systemic Immune Inflammation Index with Estimated Pulse Wave Velocity, Atherogenic Index of Plasma, Triglyceride-Glucose Index, and Cardiovascular Disease: A Large Cross-Sectional Study
Table 1
Distribution of baseline characteristics of NHANES cohort across quartiles of SII index.
SII index
Overall
Q1
Q2
Q3
Q4
value
Age (years)
<0.001
Gender (%)
<0.001
Male
8883 (51.1%)
2469 (14.2%)
2327 (13.4%)
2136 (12.3%)
1951 (11.2%)
Female
8506 (48.9%)
1879 (10.8%)
2020 (11.6%)
2210 (12.7%)
2397 (13.8%)
Race (%)
<0.001
Mexican American
3008 (17.3%)
687 (4.0%)
828 (4.8%)
799 (4.6%)
694 (4.0%)
Other Hispanic
1374 (7.9%)
314 (1.8%)
370 (2.1%)
360 (2.1%)
330 (1.9%)
Non-Hispanic black
3325 (19.1%)
1301 (7.5%)
771 (4.4%)
672 (3.9%)
581 (3.3%)
Non-Hispanic white
8264 (47.5%)
1584 (9.1%)
2006 (11.5%)
2204 (12.7%)
2470 (14.2%)
Other race
1418 (8.2%)
462 (2.7%)
372 (2.1%)
311 (1.8%)
273 (1.6%)
Family PIR
<0.001
Education level (%)
<0.001
Less than high school
4394 (25.3%)
1060 (6.1%)
1105 (6.4%)
1126 (6.5%)
1103 (6.3%)
High school
1513 (8.7%)
484 (2.8%)
381 (2.2%)
304 (1.7%)
344(7.9%)
More than high school
11482 (66.0%)
2804 (16.1%)
2861 (16.5%)
2916 (16.8%)
2901 (16.7%)
Marital status (%)
<0.001
Having a partner
10727 (61.7%)
2689 (15.5%)
2790 (16.0%)
2725 (15.7%)
2523 (14.5%)
No partner
3723 (21.4%)
817 (4.7%)
849 (4.9%)
904 (5.2%)
1153 (6.6%)
Unmarried
2939 (16.9%)
842 (4.8%)
708 (4.1%)
717 (4.1%)
672 (3.9%)
Smoker (%)
<0.001
No
9210 (53.0%)
2472 (14.2%)
2408 (13.8%)
2294 (13.2%)
2036 (11.7%)
Former
4495 (25.8%)
1060 (6.1%)
1131 (6.5%)
1109 (6.4%)
1195 (6.9%)
Now
3648 (21.2%)
816 (4.7%)
808 (4.6%)
943 (5.4%)
1117 (6.4%)
Alcohol user (%)
<0.001
Never
2296 (13.2%)
601 (3.5%)
578 (3.3%)
586 (3.4%)
531 (3.1%)
Former
3008 (17.3%)
708 (4.1%)
697 (4.0%)
728 (4.2%)
875 (5.0%)
Mild
6001 (34.5%)
1566 (9.0%)
1498 (8.6%)
1501 (8.6%)
1436 (8.3%)
Moderate
2583 (14.9%)
646 (3.7%)
663 (3.8%)
635 (3.7%)
639 (3.7%)
Heavy
3501 (20.1%)
827 (4.8%)
911 (5.2%)
896 (5.2%)
867 (5.0%)
Hypertension (%)
<0.001
No
9899 (56.9%)
2583 (14.9%)
2616 (15.0%)
2456 (14.1%)
2244 (12.9%)
Yes
7490 (43.1%)
1765 (10.2%)
1731 (10.0%)
1890 (10.9%)
2104 (12.1%)
DM (%)
<0.001
No
14160 (81.4%)
3616 (20.8%)
3551 (20.4%)
3569 (20.5%)
3424 (19.7%)
Yes
3229 (18.6%)
732 (4.2%)
796 (4.6%)
777 (4.5%)
924 (5.3%)
CHD (%)
0.037
No
16682 (95.9%)
4190 (24.1%)
4196 (24.1%)
4170 (24.0%)
4126 (23.7%)
Yes
707 (4.1%)
158 (0.9%)
151 (0.9%)
176 (1.0%)
222 (1.3%)
CHF (%)
<0.001
No
16886 (97.1%)
4240 (24.4%)
4252 (24.5%)
4231 (24.3%)
4163 (23.9%)
Yes
503 (2.9%)
108 (0.6%)
95 (0.5%)
115 (0.7%)
185 (1.1%)
Angina (%)
0.180
No
16907 (97.2%)
4237 (24.4%)
4230 (24.3%)
4249 (24.4%)
4191 (24.1%)
Yes
482 (2.8%)
111 (0.6%)
117 (0.7%)
97 (0.6%)
157 (0.9%)
Heart attack (%)
<0.001
No
16671 (95.9%)
4182 (24.0%)
4203 (24.2%)
4188(24.1%)
4098 (23.6%)
Yes
718 (4.1%)
166 (1.0%)
144 (0.8%)
158 (0.9%)
250 (1.4%)
Stroke (%)
0.001
No
16765 (96.4%)
4221 (24.3%)
4210 (24.2%)
4197 (24.1%)
4137 (23.8%)
Yes
624 (3.6%)
127 (0.7%)
137 (0.8%)
149 (0.9%)
211 (1.2%)
Hyperlipidemia (%)
<0.001
No
4666 (26.8%)
1357 (7.8%)
1180 (6.8%)
1051 (6.0%)
1078 (6.2%)
Yes
12723 (73.2%)
2991 (17.2%)
3167 (18.2%)
3295 (18.9%)
3270 (18.8)
CVD (%)
<0.001
No
15562 (89.5%)
3936 (22.6%)
3692 (22.8%)
3906 (22.5%)
3458(21.6%)
Yes
1827 (10.5%)
412 (2.4%)
385 (2.2%)
440 (2.5%)
590 (3.4%)
BMI (kg/m2)
<0.001
Waist circumference (cm)
<0.001
Hb (g/dL)
<0.001
FBG (mg/dL)
<0.001
HDL-C (mg/dL)
<0.001
TC (mg/dL)
0.001
TG (mg/dL)
0.003
CCI
<0.001
ePWV
<0.001
AIP
<0.001
HOMA IR
<0.001
TyG index
<0.001
Abbreviations: Q1: 1.529-330.179; Q2: 330.180-463.273; Q3: 463.274-654.615; Q4: 654.616-28397.276; NHANES: National Health and Nutrition Examination Survey; SII: systemic immune inflammation; PIR: poverty income ratio; DM: diabetes mellitus; CHD: coronary heart disease; CHF: congestive heart failure; CVD: cardiovascular disease; BMI: body mass index; Hb: hemoglobin; FBG: fast glucose; HDL-C: high-density lipoprotein cholesterol; TC: total cholesterol; TG: triglyceride; CCI: Charlson comorbidity index; ePWV: estimated pulse wave velocity; AIP: atherogenic index of plasma; HOMA IR: insulin resistance index; TyG: triglyceride-glucose.
