HMGB2 Deficiency Mitigates Abdominal Aortic Aneurysm by Suppressing Ang-II-Caused Ferroptosis and Inflammation via NF-κβ Pathway

Figure 2

HMGB2 deficiency enhanced viability and inhibited apoptosis in Ang-II-treated VSMCs. shHMGB2#1, shHMGB2#2, or shHMGB2#3 were transfected into Ang-II-treated VSMCs to detect the expression of HMGB2 (a). The Ang-II-induced VSMCs were treated with shNC or shHMGB2#3. HMGB2 mRNA and protein level were detected (b and c). CCK-8 and flow cytometry assays were performed to assess Ang-II-treated VSMC viability and apoptosis (d and e). ELISA assay detected IL-6 and IL-1β in Ang-II-treated VSMCs (f).

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