Increased Expression of Long Noncoding RNA LOC100506314 in T cells from Patients with Nonsegmental Vitiligo and Its Contribution to Vitiligo Pathogenesis

<div>Effect of LOC100506314 overexpression in jurkat cells on downstream signaling pathway of STAT3 and MIF. LOC100506314 was overexpressed in Jurkat cells using transfection with plasmid encoding LOC100506314 and an empty plasmid was used for the control. (a) The transfection of plasmid encoding LOC100506314 effectively increased the expression of LOC100506314 in jurkat cells. (b) The transfection of LOC100506314 suppressed the phosphorylation of STAT3. (c) The transfection of LOC100506314 decreased the nuclear protein levels of p65. (d) The transfection of LOC100506314 decreased the phosphorylation of AKT. (e) The phosphorylation of ERK was also suppressed after the transfection of LOC100506314.</div>

Mediators of Inflammation

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Figure 5

Figure 5: Increased Expression of Long Noncoding RNA LOC100506314 in T cells from Patients with Nonsegmental Vitiligo and Its Contribution to Vitiligo Pathogenesis 

Figure 5 | Increased Expression of Long Noncoding RNA LOC100506314 in T cells from Patients with Nonsegmental Vitiligo and Its Contribution to Vitiligo Pathogenesis 