Increased Expression of Long Noncoding RNA LOC100506314 in T cells from Patients with Nonsegmental Vitiligo and Its Contribution to Vitiligo Pathogenesis

<div>Roles of abnormal T-cell expression of LOC100506314 in the immune pathogenesis of vitiligo. The expression levels of LOC100506314 increased in T cells from patients with vitiligo. LOC100506314 could bind STAT3 and MIF and suppressed STAT3, AKT, and ERK phosphorylation and decreased nuclear protein levels of p65, resulting decreased expression of IL-6 and IL-17. Therefore, LOC100506314 appeared to play a negative feedback role for vitiligo immune pathogenesis.</div>

Mediators of Inflammation

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Figure 8: Increased Expression of Long Noncoding RNA LOC100506314 in T cells from Patients with Nonsegmental Vitiligo and Its Contribution to Vitiligo Pathogenesis 

Figure 8 | Increased Expression of Long Noncoding RNA LOC100506314 in T cells from Patients with Nonsegmental Vitiligo and Its Contribution to Vitiligo Pathogenesis 