ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway

Figure 1

Downregulation of ANGPTL2 improved isoflurane-induced cognitive dysfunction in mice. (a) Pathological change was detected using HE staining. (b) ANGPTL2 mRNA level was measured using qRT-PCR. (c, d) Western blotting was used to examine expression of ANGPTL2 and β-actin protein level. (e) HE staining was performed to observe pathological change. (f, g) Morris water maze task was used to detect escape latency time, target quadrant time, and platform crossing time. (h) FCT was carried out to measure freezing time to context test and freezing time to tone test. . ; .

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