The Spliceosome Factor EFTUD2 Promotes IFN Anti-HBV Effect through mRNA Splicing

Figure 5

EFTUD2 regulation of classical ISGs did not act through direct regulation of the JAK-STAT pathway. (a–d) RT-qPCR detected the STAT1, IRF9, IFNAR1, and JAK1 mRNA in WT and EFTUD2^+/-HepG2.2.15 cells before and after IFN treatment. (e) After incubated with 5000 IU/mL IFN-α for 24 h, STAT1 and STAT1 phosphorylation (P-STAT1) were assessed by Western blotting in WT and EFTUD2^+/-HepG2.2.15 cells.

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