The Spliceosome Factor EFTUD2 Promotes IFN Anti-HBV Effect through mRNA Splicing

Figure 7

A proposed model for EFTUD2 in IFN-induced anti-HBV effect. The binding of IFN-α to type I IFN receptor activates the JAK-STAT pathway, ISRE transcription is initiated through signal transduction, and ISG expression is induced. EFTUD2 exerts its anti-HBV action through differential splicing of some ISGs, including Mx1, OAS1, and PKR. Furthermore, these antiviral proteins provide direct antiviral effects at various stages of the HBV life cycle.