Research Article

Effects of CAR-T Cell Therapy on Immune Cells and Related Toxic Side Effect Analysis in Patients with Refractory Acute Lymphoblastic Leukemia

Table 1

CRS grade.

IndicatorsGrade 1Grade 2Grade 3Grade 4

FeverBody temperature ≥ 38°CBody temperature ≥ 38°CBody temperature ≥ 38°CBody temperature ≥ 38°C
HypotensionNoNo need to use antihypertensive drugs1 antihypertensive drug is required, with or without vasopressinMultiple antihypertensive drugs are required (excluding vasopressin)
And/or
HypoxemiaNoNeed low flow nasal catheter oxygen inhalationNeed high flow nasal catheter oxygen inhalation and circulatory respiratorNeed positive pressure ventilation