Betulinic Acid Attenuates Osteoarthritis via Limiting NLRP3 Inflammasome Activation to Decrease Interleukin-1β Maturation and Secretion

<div>BA inhibited ASC oligomerization and speck formation. (a) Representative image of ASC oligomerization by western bolt. (b) Representative image of ASC speck formation and quantification. Scale bar 100 µm (panel) 10 µm (inset). (c) The analysis of GSDMD by western blot. (d) Representative image of Calcein/PI staining; scale bar = 250 µm. (n = 3).</div>

Mediators of Inflammation

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Figure 10

Figure 10: Betulinic Acid Attenuates Osteoarthritis via Limiting NLRP3 Inflammasome Activation to Decrease Interleukin-1β Maturation and Secretion