LIGHT Amplification by NF-κB Contributes to TLR3 Signaling Pathway-Induced Acute Hepatitis

Figure 1

TLR3 signaling triggered acute hepatitis. (a) BALB/c mice were injected with poly(I:C) (1.5 μg/mouse) and D-GalN(10 mg/mouse). At the 8 h, 16 h, and 24 h time points, serum ALT was measured. The figure shows the results of one representative experiment with eight mice per group, and data are shown as ; , , . (b) The mice were sacrificed at 24 h after treatment with saline or poly(I:C). Liver sections were stained with H&E staining (size bar represents 50 μm). Arrows indicate necrotic areas with accumulation of mononuclear cells.

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