Cancer-Associated Fibroblast Risk Model for Prediction of Colorectal Carcinoma Prognosis and Therapeutic Responses

Figure 3

WGCNA was used to explore stromal CAF-related hub-genes and perform functional enrichment analysis. The soft-thresholding power in GSE39582 (a) and TCGA-COAD (b) cohorts. Clustering dendrograms exhibiting hub-genes with alike expression profiles were converged into coexpression modules in GSE39582 (c) and TCGA-COAD (d) cohorts. MEturquoise module was most closely connected with the CAF proportion and stromal score in GSE39582 (e) and TCGA-COAD (f) cohorts. (g) Venn diagram showed the shared hub-genes in GSE39582 and TCGA-COAD cohorts. (h) GO enrichment analysis of 88 shared hub-genes. (i) KEGG enrichment analysis of 88 shared hub-genes.

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