Research Article

lncRNA MIR503HG Targets miR-191-5p/PLCD1 Axis and Negatively Modulates Apoptosis, Extracellular Matrix Disruption, and Inflammation in Abdominal Aortic Aneurysm

Figure 4

PLCD1 overexpression weakened miR-191-5p mimic-mediated AAA progression. (a) The overexpression efficiency of pcDNA3.1/PLCD1 (PLCD1) in VSMCs was evaluated. (b–f) The viability and apoptosis in three groups of differentially transfected VSMCs were analyzed. (g, h) The levels of proliferation/apoptosis-related proteins and proteins related to ECM degradation in each group were tested. (i, j) Serum levels of inflammatory cytokines in each sample. Three biological replicates were involved for each experiment. .
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