Thiostrepton-Nanomedicine, a TLR9 Inhibitor, Attenuates Sepsis-Induced Inflammation in Mice

<div>Biomarkers of hepatic and renal injury. C57BL/6 mice (5–6 per group) underwent CLP or SHAM surgery. CLP animals received empty micelles (SSM) or thiostrepton nanomedicine (TST-SSM) i.p. at 6 hr, and all animals were euthanized at 24 hr. (a, b) Hepatic biomarkers (AST and ALT) and (c, d) renal biomarkers (BUN and creatinine) were measured from heparinized plasma samples. Values are mean ± standard error mean. One-way ANOVA analyzed results with Tukey’s multiple comparisons. 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Mediators of Inflammation

fig3

Figure 3

Figure 3: Thiostrepton-Nanomedicine, a TLR9 Inhibitor, Attenuates Sepsis-Induced Inflammation in Mice 