Protease-Activated Receptor-2 and Phospholipid Metabolism Analysis in Hyperuricemia-Induced Renal Injury

Figure 3

The effects on renal injury in hyperuricemia rats induced by PAR2 antagonist AZ3451. (a) Representative images of HE staining. The red arrows show tubular lumen dilatation and tubular epithelial cell necrosis. The yellow arrows show the brown crystals. The blue arrows show the inflammatory cells. The green arrows show glomerular damage. (b) The tubular injury and inflammatory cell infiltration score for HE staining. (c) The level of XOD activity, UA, Cr, BUN, KIM-1, and NGAL in rat serum. Before: before intraperitoneal administration of the control reagent or AZ3451. After 6 weeks of intraperitoneal administration of the control reagent or AZ3451. Data are presented as means ± standard deviation. n = 20 per group; ns, not significant. . HU, hyperuricemia; XOD, xanthine oxidase; UA, uric acid; Cr, creatinine; BUN, blood urea nitrogen; NGAL, neutrophil gelatinase-associated lipocalin; KIM-1, kidney injury molecule-1.

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