Protease-Activated Receptor-2 and Phospholipid Metabolism Analysis in Hyperuricemia-Induced Renal Injury

Table 1

Differentially changed phospholipid species in HU and HU + AZ3451 group.

No	tR (min)	MRM transitions	Metabolite identification	Fold change	Regulation	p
1	1.28	833.5/255	PI (16 : 0/18 : 2)	0.83	Down	0.52
2	1.45	835.5/255	PI (16 : 0/18 : 1)	0.99	Down	0.86
3	1.22	857.5/303	PI (16 : 0/20 : 4)	0.69	Down	0.90
4	1.52	861.5/283	PI (18 : 0/18 : 2)	0.94	Down	0.51
5	3.52	812/184	PC (18 : 0/20 : 3)	1.49	Up	0.05
6	0.73	568/184	LPC (22 : 6)	1.36	Up	0.05
7	0.74	546/184	LPC (20 : 3)	1.63	Up	0.05
8	0.77	542/184	LPC (20 : 5)	1.88	Up	0.04
9	0.79	468/184	LPC (14 : 0)	1.72	Up	0.03

tR, retention time, the amount of time a compound spends on the column after it has been injected. MRM, multiple reaction monitoring. MRM transitions, the precursor ions and production. Fold change, compared with the HU group, the phospholipid quantity changes in the HU + AZ3451 group.