RhoA Promotes Synovial Proliferation and Bone Erosion in Rheumatoid Arthritis through Wnt/PCP Pathway

Figure 5

Mechanism research of RhoA involved in synovitis and bone erosion. (a) Relative mRNA expression levels of JNK, JAK2, STAT3, ROCK2, and NF-κB in transfected RA-FLSs, p = 0.380, 0.016, 0.025, 0.004, 0.321. (b and c) The protein levels of RhoA (), ROCK2 (), and pSTAT3 () in the RA-FLSs of indicated groups determined by western blot. (d–f) The mRNA levels of ROCK2 (d, ), c-Fos (e, ), and NFATc1 (f, , 0.014) in the process of transfected BMMCs differentiating into OC. (g) IP analysis showed that RhoA interacted with ROCK2 in RA-FLSs. (h) IP analysis showed that ROCK2 interacted with pSTAT3. , , .

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