Dimethyl Fumarate Protects against Lipopolysaccharide- (LPS-) Induced Sepsis through Inhibition of NF-κB Pathway in Mice

Figure 3

DMF protected against mortality and attenuated excessive inflammation in septic mice. C57BL/6 mice were administered DMF (30 mg/kg, gavage) or vehicle (saline) 30 min through injection before LPS injection (20 mg/kg, i.p.), survival was noted at various times, and the sera were collected. (a) The model diagram of the animal experiment is shown. (b) The log-rank test was employed to evaluate the statistical significance of survival rate. The mice had 100% mortality at 74 hr in the sepsis model. Treatment with DMF before the LPS challenge could increase the survival rate of mice by 50% compared with the sepsis model group. (c) Mouse cytokine array panel was to assess the generation of TNF-α, IL-6, and IL-10. The cytokines were inhibited after DMF administion in comparison with the LPS control group. The data are presented as the mean ± SD of three independent samples. The student’s t-test determined the statistical significance. .

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