Mediators of Inflammation

Research Article

Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study

Table 1

Clinical characteristics of the study cohort.


General characteristics	Overall ()	Without CHF ()	With CHF ()	^a

Age (y)				0.39
Male, (%)	164 (58)	107 (60)	57 (54)	0.34
MAP (mmHg)				0.18
BMI (kg/m²)				0.86
Primary renal diseases, (%)				0.06
Chronic glomerulonephritis	204 (72)	135 (76)	69 (66)
Diabetic nephropathy	39 (14)	19 (11)	20 (19)
Hypertensive nephropathy	34 (12)	18 (10)	16 (15)
Others	6 (2)	6 (3)	0 (0)
Comorbidities, (%)
Diabetes mellitus	39 (14)	19 (11)	20 (19)	0.05
Hypertension	264 (93)	165 (93)	99 (94)	0.61
Baseline lab examinations
Serum creatinine (μmol/l)				0.54
Serum albumin (g/l)				0.002
Blood hemoglobin (g/l)				0.19
Serum phosphate (mmol/l)				0.86
Serum PTH (pg/ml)				0.09
Serum MMP7 (ng/ml)				0.03
Ln dialysate MMP7 (pg/ml)				0.003
LVEF, %				<0.001
Baseline PD characteristics
PD modality, (%)
CAPD	265 (94)	164 (92)	101 (96)	0.18
Type of dialysates, (%)
Conventional	283 (100)	178 (100)	105 (100)	—
Dialysate GLUC, %				0.08
UF volume (ml/24 h)	200 (-175-400)	200 (-200-450)	200 (-100-400)	0.68
Urine volume (L/24 h)				0.74
KT/V score				0.32
D/P creatinine ratio				0.27
PD vintage,	21 (11-37)	19 (11-33)	29 (12-44)	0.01
Medication, (%)
Antihypertensive drugs	262 (93)	162 (91)	100 (95)	0.19
Outcomes, (%)
Death	20 (7)	9 (5)	11 (11)	0.10
PD withdrawal	93 (33)	57 (32)	36 (34)	0.70

Continuous variables were expressed as or median (25th percentile-75th percentile). Categorical variables were expressed as (%). MAP, BMI, Ln dialysate MMP7, KT/V, and PET were calculated by the formulas mentioned before. CHF: congestive heart failure; MAP: mean arterial pressure; BMI: body mass index; ESRD: end-stage renal disease; PTH: parathyroid hormone; MMP7: matrix metalloproteinase-7; LVEF: left ventricular ejection fraction; PD: peritoneal dialysis; CAPD: continuous ambulatory peritoneal dialysis; GLUC: glucose concentration; UF: ultrafiltration; PET: peritoneal equilibration test. ^a for comparisons between with and without CHF groups by -test, Kruskal-Walli’s test, or chi-squared test for continuous and categorical variables, respectively.