Key Roles of p53 Signaling Pathway-Related Factors GADD45B and SERPINE1 in the Occurrence and Development of Gastric Cancer

Figure 9

Molecular mechanism plot of GADD45B (a) and SERPINE1 (b) affecting biological characteristics of GC cells. GADD45B is downregulated, while SERPINE1 is upregulated in GC. Overexpression of GADD45B can inhibit the proliferation, migration, and invasion of GC cells and promote their apoptosis, while overexpression of SERPINE1 can promote the proliferation, migration, and invasion of GC cells and inhibit their apoptosis. GADD45B and SERPINE1 may be key genes participating in GC development.

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