ANXA1sp Protects against Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death via SIRT3-Mediated p53 Deacetylation

Figure 2

ANXA1sp inhibits LPS-caused oxidative stress and ferroptosis in H9C2 cardiomyocytes. H9C2 cells were assigned to control, LPS, and LPS+ANXA1sp groups. (a–d) ROS, MDA, SOD, and GSH levels in H9C2 cell supernatant. (e) Iron accumulation in H9C2 cells. (f) WB for levels of ferroptosis-related proteins (GPX4 and FTH1) in H9C2 cells. The experiments were repeated three times (). Data were presented as . All statistical analyses were performed using Student’s -test or one-way ANOVA. ; ; .

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