Integrative Analysis of Clinical and Bioinformatics Databases to Reveal the Role of Peripheral Innate Immunity in Kawasaki Disease

Figure 2

Immunity-related gene (IRG) scores of PBMC clusters in KD. (a) DEGs in cell clusters from KD samples. Myeloid cells had the most DEGs. (b) Scores of 381 screened IRGs. The threshold was 0.11. (c) t-SNE plots of IRG scores in all clusters. Myeloid cells express more genes and exhibit higher AUC values. (d) Gene Ontology (GO) analysis of DEGs in myeloid cells, revealing enrichment in immune response-activated cell surface receptor signaling pathway and immune response-activated signal transduction. (e) KEGG analysis of DEGs in myeloid cells, revealing enrichment in pathways associated with Th17 cell differentiation, cytokine–cytokine receptor interaction, and natural killer cell-mediated cytotoxicity.

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