Integrative Analysis of Clinical and Bioinformatics Databases to Reveal the Role of Peripheral Innate Immunity in Kawasaki Disease

Figure 7

Analysis of DEGs across KD phenotypes (GSE63881): acute IVIG-responsive KD, acute IVIG-resistant KD, convalescent IVIG-responsive KD, and convalescent IVIG-resistant KD. (a) Cluster analysis of differentially expressed IRGs. Each color represents a module in the gene coexpression network constructed using weighted gene coexpression network analysis (WGCNA). (b) Membership in the blue module, showing DEGs that were positively correlated with IVIG-responsive KD phenotypes. (c) These DEGs are primarily associated with neutrophil activation, neutrophil degranulation, and neutrophil-mediated immunity.

(a)

(b)

(c)