AdipoRon Engages Microglia to Antinociception through the AdipoR1/AMPK Pathway in SNI Mice

Figure 2

AdipoRon reduced the protein expression of TNF-α and the number of Iba-1-positive cells in the ipsilateral spinal cord of SNI mice. (a, b) Representative blots and quantification of the effect of AdipoRon on the TNF-α protein expression in the ipsilateral spinal cord of mice on day 7 after SNI. (c) Representative fluorescence images of microglia in the ipsilateral SDH (spinal dorsal horn) of mice on day 7 after SNI. Scale bar: 400 μM and 200 μM. (d) Summarized data for microglia numbers in the ipsilateral SDH from the three groups shown in (c). Data were presented as ( per group). vs. Sham-Ipsi, ^# vs. SNI+Vehicle-Ipsi, ^&&&& vs. Sham, and ^$$ vs. SNI.

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