AdipoRon Engages Microglia to Antinociception through the AdipoR1/AMPK Pathway in SNI Mice

Figure 4

AdipoRon inhibited LPS-induced TNF-α expression in BV2 cells. (a) Effects of different concentrations of LPS on the expression of TNF-α in BV2 cells. (b) Timeline of in vitro experiments. (c) Effects of different concentrations of AdipoRon on the proliferation of BV2 cells. (d) AdipoRon at a concentration of 50 μM inhibited the expression of TNF-α induced by LPS in BV2 cells. (e, f) Effects of AdipoRon at a concentration of 50 μM on the LPS-induced polarization imbalance in BV2 cells. All results were presented as (). , , and vs. 0 ng/ml, ^## vs. 0 μM, ^&&& and ^&&&& vs. Naive, and ^$$$ and ^$$$$ vs. LPS.

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