Key Cell Types and Biomarkers in Heart Failure Identified through Analysis of Single-Cell and Bulk RNA Sequencing Data

Figure 6

Classification and molecular characterization of myeloid cell subsets: (a) UMAP plots of 12 subclusters of myeloid cells; (b) UMAP plots of myeloid subsets, colored by DCM, ICM, and normal groups; (c) comparison for gene expression of CXCR4 and CD74 in 12 myeloid cell subsets; (d) heatmap of the most variable TFs activity among different myeloid subsets; (e, f) comparison for the distribution of transcription factor activities of NF-κB and RELA in 12 myeloid cell subsets; (g, h) comparison for proportions of different myeloid cell subclusters in three groups (DCM, ICM, and normal) and three sampling regions (blood, LV, and RV), LV: left ventricle. RV: right ventricle, MI: infarcted myocardium, NMI: noninfarcted myocardium.

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