Key Cell Types and Biomarkers in Heart Failure Identified through Analysis of Single-Cell and Bulk RNA Sequencing Data

Figure 8

Macrophage phenotype transformation: (a, b) UMAP visualization of cells ordered along trajectories with monocle 3 and labeled by defined myeloid cell subsets (a) or by inferred pseudotime (b); (c, e) cells trajectory analysis in DCM (c) and ICM (e), including the CD14⁺ monocyte subset, Mφ1 subset, Mφ2 subset, Mφ4 subset, and TREM2⁺ Mφ, colored by identified subset or inferred pseudotime with monocle3; (d, f) pseudotime kinetics of indicated genes from cell subset of DCM (d) and ICM (f).

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