Mucus Hypersecretion in Chronic Obstructive Pulmonary Disease and Its Treatment

Table 3

Interventional bronchoscopy procedure.

Interventional bronchoscopy procedure	Aim
Bronchial rheoplasty	Reduces symptoms and goblet cell hyperplasia by delivering nonthermal pulsed electric fields to mucus-producing airway cells
Resector balloon desobstruction	Through bronchial lumen, a resector latex balloon is inflated and deflated causing disruption of hyperplastic goblet cells
Targeted lung denervation (TLD)	Bronchoscopy radiofrequency ablation is used to disrupt pulmonary parasympathetic nervous system, which is responsible for airway inflammation and mucus hypersecretion
Spray cryotherapy	Uses nitrogen spray, which can induce airway tissue repair without scaring by destroying hyperplastic goblet cells and excess submucosal glands