LINC01088/miR-22/CDC6 Axis Regulates Prostate Cancer Progression by Activating the PI3K/AKT Pathway

Figure 1

LINC01088 is a new potential target that promotes PCa development. (a) Hierarchical clustering heat map shows differentially expressed lncRNA including LINC01088 between the PCa and control groups. (b) Relative expression levels of LINC01088 between the PCa tumor tissues and adjacent tissues. (c) The disease-free survival rate was calculated in the LINC01088-high or LINC01088-low groups by TCGA survival analysis on the GEPIA2 database. (d) Relative expression of LINC01088 in RWPE-2 and four PCa cell lines (C4-2, 22RV1, PC3, and LNCaP). (e) RT-qPCR analysis of the inhibition efficiency of 3 si-LINC01088 in PC3 and LNCAP cells. CCK8 analysis of the effect of si-LINC01088 on the viability rate of (f) PC3 and (g) LNCAP cells. Transwell analysis of the effects of si-LINC01088 on migration and invasion of (h) PC3 and (i) LNCAP cells. (j) RT-qPCR analysis of LINC01088 localization in PC3 and LNCAP cells. .

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