LINC01088/miR-22/CDC6 Axis Regulates Prostate Cancer Progression by Activating the PI3K/AKT Pathway

Figure 2

LINC01088 sponge adsorbs miR-22. (a) Hierarchical clustering heat map shows differentially expressed miRNA between the PCa and control groups. (b) The miRNA chip and the lncRNA database were combined to analyze the potential miRNAs that bind to LINC01088. (c) Relative expression of miR-22 between the PCa tumor tissues and adjacent tissues. (d) Relative expression of miR-22 in RWPE-2 and four PCa cell lines (C4-2, 22RV1, PC3, and LNCaP). (e) RT-qPCR analysis of the effect of si-LINC01088 on the expression of miR-22 in PC3 and LNCAP cells. (f) Dual-luciferase assay analysis of the binding of LINC0108 to miR-22. .

(a)

(b)

(c)

(d)

(e)

(f)