Research Article

A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling

Figure 3

(a) The effect of different LPS concentrations on the expression of RANKL mRNA in osteoblasts. (b) The effect of 100 mg/mL LPS and AGEs on the expression of RANKL mRNA in osteoblasts. (c) The effects of LPS and AGE stimulation at optimum concentration for different times on RANKL mRNA expression in osteoblasts. (d, e) The effects of LPS and AGE stimulation at optimum concentration for different times on the expression of RANKL protein in osteoblasts (repeat three times). (f) The effect of LMT-28 on RANKL mRNA expression in osteoblasts. (g) The effects of stimulation at optimal LMT-28 concentration for different time on RANKL mRNA expression in osteoblasts. (h, i) The effects of stimulation at LMT-28 optimal concentration for different time on the expression of RANKL protein in osteoblasts (repeat three times; , , ).
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